| Numerical Simulation of Microwave Ablation in Porous Human Liver |
| کد مقاله : 1340-ISME2026 |
| نویسندگان |
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مهکامه شربتدار *1، مریم کریم سرمدی2 1دانشکده مهندسی مکانیک، دانشگاه صنعتی خواجه نصیرالدین طوسی 2دانشکده مهندسی مکانیک دانشگاه صنعتی خواجه نصیرالدین طوسی |
| چکیده مقاله |
| Hepatocellular carcinoma is frequently diagnosed at intermediate or advanced stages, where curative resection is often not feasible. In such cases, locoregional therapies must achieve effective tumor control while rigorously preserving healthy liver parenchyma, which is especially critical in a metabolically vital and often compromised organ. This clinical imperative underscores the urgent need for predictive, physics-based planning tools capable of simulating the complex interplay between electromagnetic heating, tissue damage, and drug delivery dynamics, thereby enabling safer and more selective hyperthermia-based interventions. Microwave hyperthermia combined with thermosensitive liposomal doxorubicin delivery is studied numerically using a multiphysics model that couples electromagnetic wave propagation at 2.45 GHz, Pennes bioheat transfer, Darcy-based interstitial flow, and temperature-triggered drug release in a 2D axisymmetric ideal liver geometry. Thermal damage is evaluated via an Arrhenius model, and drug efficacy was quantified using the fraction of killed cells. The framework is validated by experimental data for both thermal and drug responses, showing good agreement. Quantitative results show that the non-optimized protocol (30 W for 10 min) induces extensive thermal damage in the peritumoral healthy liver tissue, at levels sufficient to potentially compromise post-treatment liver function. This collateral injury is clinically unacceptable and highlights the limitations of non-optimized heating protocols, emphasizing the need for optimized treatment strategies that preserve therapeutic efficacy while minimizing off-target effects. The model offers a reliable foundation for optimizing therapeutic strategies to improve safety and target specificity. |
| کلیدواژه ها |
| Cancer, Bioheat transfer, Drug delivery, Thermo-sensitive liposomes |
| وضعیت: پذیرفته شده برای ارائه شفاهی |